Correction of copy number induced false positives in CRISPR screens

A note on controlling the number of false positives.

Lehmann and Romano (2005, Annals of Statistics33, 1138-1154) discuss a Bonferroni-type procedure that bounds the probability that the number of false positives is larger than a specified number. We note that this procedure will have poor power as compared to a multivariate permutation test type procedure when the experimental design accommodates a permutation test. An example is given involving...

False Discovery Rates and Copy Number Variation

Copy number changes, the gains and losses of chromosome segments, are a common type of genetic variation among healthy individuals as well as an important feature in tumor genomes. Microarray technology enables us to simultaneously measure, with moderate accuracy, copy number variation at more than a million chromosome locations and for hundreds of subjects. This leads to massive data sets and ...

Clinical inquiries. What common substances can cause false positives on urine screens for drugs of abuse?

C L I N I C A L C O M M E N TA R Y False-positive reports on urine drug screens by immunoassay are rare (strength of recommendation [SOR]: C, small controlled-exposure studies, small case series). Nonsteroidal anti-inflammatory drugs, fluoroquinolones, and Vicks Inhaler are most frequently implicated (TABLE). Ruling out a false-positive result requires confirmation with a more specific test, us...

False positives in cancer epidemiology.

BACKGROUND A recent attempt to estimate the false-positive rate for cancer epidemiology studies is based on agents in International Agency for Research on Cancer (IARC) category 3 (agent not classifiable as to its carcinogenicity to humans) in the IARC Monographs Program. METHODS The estimation method is critiqued regarding biases caused by its reliance on the IARC classification criteria for...

Minimizing false positives in differential display.